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Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system
Faculty
Not Specified
Year:
2013
Type of Publication:
Article
Pages:
120-126
Authors:
Hasan, Azza A, Madkor, Hafez, Wageh, Sherief
DOI:
10.3109/10717544.2013.779332
Journal:
DRUG DELIVERY INFORMA HEALTHCARE
Volume:
20
Research Area:
Pharmacology \& Pharmacy
ISSN
ISI:000320263000004
Keywords :
Formulation , evaluation , metformin hydrochloride-loaded niosomes , controlled
Abstract:
Lactic acidosis is a serious, metabolic complication that may occur due to metformin hydrochloride (MH) accumulation during the treatment of diabetes mellitus. The aim of this study is to enhance the bioavailability of MH by oral route. Span 40 and cholesterol were used for the preparation of MH-loaded niosomes by the reverse phase evaporation technique. Dicetyl phosphate (DCP) and 1,2-dioleoyl-3-trimethylammonium-propane chloride salt (DOTAP) were used to obtain negatively and positively charged vesicles, respectively. The mean particle size ranged from 223.5 to 384.6nm and the MH-loaded niosomes' surface was negatively charged in the absence of charge inducing agents (+ 16.6 +/- 1.4 mV) and also with DCP (+ 26.9 +/- 1.0 mV), while it was positively charged (+8.7 +/- 1.2 mV) with DOTAP. High entrapment efficiency was observed in all the formulations. MH-loaded niosomes were found to effectively sustain the release of drug, particularly with positively charged niosomes. The bioavailability of MH-loaded niosomes was assessed by measuring the serum values of glucose and metformin in the different studied Wistar rats groups. The pharmacokinetic data of MH-loaded niosomal preparation showed a significant prolongation and increased intensity of hypoglycemic effect more than that observed for free MH solution. Area above the blood glucose levels-time curve (AAC), maximum hypoglycemic response and time of maximum response (T-max) were significantly higher (p<0.001) when MH was administered in niosomal form compared to free drug solution. It could be concluded that MH-loaded niosome is promising extended-release preparation with better hypoglycemic efficiency.
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