Optimization of methotrexate loaded niosomes by Box–Behnken design: an understanding of solvent effect and formulation variability

Faculty Pharmacy Year: 2017
Type of Publication: ZU Hosted Pages: 1450–1459
Authors:
Mahmoud Mokhtar AhmedIbrahiem
Journal: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY Taylor and Francis Volume: 43
Keywords : Optimization , methotrexate loaded niosomes , Box–Behnken design:    
Abstract:
Dermal drug delivery system which localizes methotrexate (MTX) in the skin is advantageous in topical treatment of psoriasis. The aim of the current study was to understand dilution effects and formulation variability for the potential fo
    
     
 
       

Author Related Publications

  • Mahmoud Mokhtar AhmedIbrahiem, "Proniosomal oral tablets for controlled delivery and enhanced pharmacokinetic properties of Acemetacin", AAPS, 2014 More
  • Mahmoud Mokhtar AhmedIbrahiem, "Taste masked orodispersible tablets of cyclosporine self-nanoemulsion lyophilized with dry silica", Pharmaceutical Development and Technology,, 2014 More
  • Mahmoud Mokhtar AhmedIbrahiem, "Pharmaceutical Studies On Certian Multicomponents Colloid Drug Delivery Systems", لايوجد, 1900 More
  • Mahmoud Mokhtar AhmedIbrahiem, "Pharmaceutical Studies On Certian Multicomponents Colloid Drug Delivery Systems", لايوجد, 1900 More
  • Mahmoud Mokhtar AhmedIbrahiem, "Phase Study and Characterization of Certain Developed Multicomponent Colloidal Systems and their Potential Application As Carriers for An Antimicrobial Agent", لايوجد, 1900 More

Department Related Publications

  • Ahmed Samer Zedan, "Physicochemical characterization and dissolution properties of rofecoxib complexes with cyclodextrins", لايوجد, 1900 More
  • Ahmed Samer Zedan, "Preparation and characterization of rofecoxib solid dispersions with polyethylene glycols and urea", لايوجد, 1900 More
  • Mahmoud Mokhtar AhmedIbrahiem, "Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes", لايوجد, 1900 More
  • Amr Selim Ahmed Ali Abu Lila, "Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration", Elsevier, 2013 More
  • Amr Selim Ahmed Ali Abu Lila, "Tumor-type-dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin", Elsevier, 2012 More
Tweet