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Spectrophotometric determination of some histamine H1-antagonists drugs in their pharmaceutical preparations
Faculty
Pharmacy
Year:
2008
Type of Publication:
Article
Pages:
245-255
Authors:
Hassan, Wafaa S, Gouda, Ayman A, El-Henawee, Magda M
DOI:
10.1016/j.saa.2007.03.040
Journal:
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY PERGAMON-ELSEVIER SCIENCE LTD
Volume:
69
Research Area:
Spectroscopy
ISSN
ISI:000252637300042
Keywords :
diphenhydramine hydrochloride (DPH), chlorphenoxamine hydrochloride (CPX), clemastine (CMT), ion-pair complexes, specrophotometry, pharmaceutical formulations
Abstract:
Two rapid, simple and sensitive extractive specrophotometric methods has been developed for the determination of three histamine H1-antagonists drugs, e.g., chlorphenoxamine hydrochloride (CPX), diphenhydramine hydrochloride (DPH) and clemastine (CMT) in bulk and in their pharmaceutical formulations. The first method depend upon the. reaction of molybdenum(V) thiocyanate ions (Method A) with the cited drugs to form stable ion-pair complexes which extractable with methylene chloride, the orange red color complex was determined colorimetrically at lambda(max) 470 nm. The second method is based on the formation of an ion-association complex with alizarin red S as chromogenic reagents in acidic medium (Method B), which is extracted into chloroform. The complexes have a maximum absorbance at 425 and 426 nm for (DPH or CMT) and CPX, respectively. Regression analysis of Beer-Lambert plots showed a good correlation in the concentration ranges of 5.0-40 and 5-70 mu g mL(-1) for molybdenum(V) thiocyanate (Method A) and alizarin red S (Method B), respectively. For more accurate analysis, Ringbom optimum concentration ranges were calculated. The molar absorptivity, Sandell sensitivity, detection and quantification limits were calculated. Applications of the procedure to the analysis of various pharmaceutical preparations gave reproducible and accurate results. Further, the validity of the procedure was confirmed by applying the standard addition technique and the results obtained in good agreement well with those obtained by the official method. (C) 2007 Elsevier B.V. All rights reserved.
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