Synthesis and reactions of some novel mercaptopyrimidine derivatives for biological evaluation

Faculty Science Year: 2008
Type of Publication: Article Pages: 2318-2329
Authors:
Moustafa, A. H, Assy, M. G, Yousif, N. M, Sayed, H. H, El-Halim, M. A. Abd
DOI: 10.1080/10426500801963590
Journal: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS TAYLOR \& FRANCIS LTD Volume: 183
Research Area: Chemistry ISSN ISI:000258384400023
Keywords : isothiazolo{[}5, 4-d]pyrimidine, pyrimidine, pyrimidio[4, 5-d]pyrimidine, pyrrolo[4, 5-d]pyrimidine, thieno[2, 3-d]pyrimidine    
Abstract:
4-Mercapto-5-acetylpyrimidine derivative was used as a precursor for preparation of some novel thieno{[}2,3-d]pyrimidine, pyrazolo{[}2,3-d]pyrimidine, isothiazolo {[}5,4-d] pyrimidine, pyrrolo{[}4,5-d]pyrimidine, and pyrimidio{[}4,5-d]pyrimidine derivatives. Furthermore, some of the prepared products were revealed promising antimicrobial activities.
    
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