Heterocyclic synthesis with thiophene-2-carboxamide

3-Amino-4-cyano-N-phenylaminothiophene-2-carboxamide (2) was prepared by reacting 2-(1,1-dicyanomethylene)-3-N-phenyl-1,3-thiazolidin-4-one (1) with ammonia. The carboxamide when reacted with benzaldehyde, formic acid, phenylisothiocyanate, cyclohexanone, cyclopentanone, ethylchloroformate and carbon disulfide yield. The pyrimidinone derivatives (3, 4, 5, 6, 7, 8, and 9), respectively. The biological activity of all synthesized compounds were studied as antibiotics and against Grain positive and Gram negative bacteria. The purpose of this article is synthesis of new antibiotic and antibacterial drugs.