Estimation of skin and gill monogenea and musculature in O. niloticus treated by praziquantel using HPLC

Treatment of skin and gill monogenea in O. niloticus with the effective drug, praziquantel which used in eradication of most helminthes in human, animals and fish. It used also in treatment of schistsomes in human being. The levels of praziquantel were determind in skin and gills (for treatment skin and gill monogenea) and musculature of O. niloticus (for determination of withholding time) with a bath treatment at 100 ppm of praziquantel for 15 minutes after 5, 10, 24, 48, 72, 96, 120 and 144 hours sampling time using HPLC. Praziquantel was highest at the 48 hours in skin and at 24 hours in gills and 10 hours in musculature (after sampling time), and it was depleted after 120 hours, 72 hours and 72 hours in skin, gills and musculature respectively in O. niloticus. {[}ife Science Journal. 2008; 5(3): 77-82] (ISSN: 1097-8135).