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Turmeric-based diet can delay apoptosis without modulating NF-kappa B in unilateral ureteral obstruction in rats
Faculty
Medicine
Year:
2008
Type of Publication:
Article
Pages:
83-89
Authors:
Hashem, Reem M, Soliman, Hala M, Shaapan, Sahar F
DOI:
10.1211/jpp.60.1.0011
Journal:
JOURNAL OF PHARMACY AND PHARMACOLOGY PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN
Volume:
60
Research Area:
Pharmacology \& Pharmacy
ISSN
ISI:000253152500011
Keywords :
Turmeric-based diet , delay apoptosis without modulating
Abstract:
The unilateral ureteral obstruction (UUO) model of renal injury in rat is characterized by nuclear factor kappa B (NF-kappa B) activation and tumour necrosis factor alpha (TNF-alpha) production, which induces apoptosis via activation of caspase 8 resulting in cell death. Curcumin, the major component found in turmeric spice, has been reported to provide protection against fibrosis and apoptosis elicited by UUO. This study examined the effects of a turmeric-based diet (5\% w/w) on the apoptotic pathway induced by UUO in rats after 30 days of ligation. Administration of a turmeric-based diet demonstrated a significant decrease (P<0.05) in mRNA expression of TNF-alpha and caspase 8, but not NF-kappa B, expression, which may contribute to the protective role of the turmeric-based diet. We conclude that a turmeric-based diet can delay apoptosis without modulating NF-kappa B, so as not to sensitize the mesangial cells to the apoptotic stimuli.
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