Biochemical assessment of silver nanoparticles on erlich ascites carcinoma in an experimental animal

Cancer is considered one of the most common causes of mortality worldwide. The target of much research has been onthe discovery of natural and synthetic compounds that can be used in the prevention and/or treatment of cancer, in this research we focused on silver nanoparticles as anti -canceragents.The application of silver nanoparticles as anticancer agent was done through using 54 female swiss albino mice whichdivided into 5 different groups as following:Group I (negative control group) Group 2 (positive control group): induction of tumor (was inoculated with 2.5 x106 EAC cells Lp) and no treatment with silver nanoparticles.(Treated groups): induction of tumor (was inoculated with 2.5 xl06 EAC cells Lp) and treated with AgNPs and this group divided into 3 subgroups according to the dose of treatment:The first dose 3.91ul of nanosilver solution daily i.p foreach mice. (group3).The second dose 7.83ul of nanosilver solution daily i.p foreach mice. (group4).The third dose 15.66 ul of nanosilver solution daily i.p foreach mice. (group5).After 5 and 10 days from injection of nanosilver theanimals were sacrificed. Blood samples were taken forseparation of serum an measurment of tumor markers (CEA andCAts.3). Ascetic fluid samples were taken for doing viability test