Protective effect of curcumalonga on fentromethrin intoxicated albino rats

Summary:-The lives and health of millions of people were suffering from the rapid rise of degenerative diseases worldwide which is threatening economic and social development. As the base of many of the diseases is food/feed stuff contamination so many toFirstly beginning by determination of LD50 of fentromethrin to facilitate the other experiments.We aimed to establish the toxic effects of fentromethrin (1/20 LD50) on 152mature male albino rats after 65 days exposure, with special reference to the possibIn this study we recorded that fentromethrin caused significant increase of MDA in liver, brain and testes; highly significant decrease of GSH (but remain within the normal limits in brain), CAT levels, vit A and vit E in liver, brain and testes, also higMDA was highly near to the control levels in liver and brain of rats dosed with C. longa rhizomal powder and fentromethrin, while level of GSH is normal in brain and insignificantly decreased in liver when compared to control group, also CAT levels in botBoth SOD and Gpx were significantly increased in serum of rats treated with C. longa rhizomal powder and non-significantly increased in rats treated with C. longa rhizomal powder and fentromethrin comparing to control group.T3 decreased than the control, T4 was insignificantly decreased in rats treated with fentromethrin as compared to control group, also testosterone decreased significantly. Normal levels of T3, T4 and testosterone were observed in rats treated with both C.All enzymatic and non-enzymatic antioxidants and the hormones (T3, T4 and testosterone) demonstrated improved levels even more than normal after administration of C. longa rhizomal powder only. Rats treated with fentromethrin revealed insignificant decreaHistochemistry study revealed marked decrease in DNA and RNA of hepatocytes, cerebral neurons, thyroid follicle epithelium and seminiferous tubular epithelium after dosing with fentromethrin, while DNA and RNA reaction appeared to be strong after co-treatThe DNA and RNA stain ability were better than any of the other groups after C.longa rhizomal powder administration.The present study clearly indicated the chemoprotective role of C.longa and suggests its potential use in status of fentomethrin toxicity.