Modulatory role of pre- and post- treament of spirulina platensis powder on toxicological effects of mitomycin C in ehrlich ascites carcinoma bearing mature female swiss albino mice

The chemotherapeutic agents are double-edged sword where they are able to kill cancer cells, and at the same time kill the normal cells leading to detrimental effects on the body. This hadto be thinking in the use of natural materials with them to reducethe harmful effects.In the present study, Sixty adult female Swiss albino mice weighted 30-40 gm were obtained from the Laboratory Animal Housing Unit, Animal Health, Research Institute, Dokki, Cairo,Egypt. The animals were clinically healthy, kept under hygienicconditions.Housed in metal cages with hard wood shavings as bedding. They were maintained on balanced ration; water and the feed were giving ad-libtum through out the experimentalperiod.The animals were accommodated to the laboratory conditions for one week before beginning of experiment, theanimals were inoculated with EAC. The animals divided into six equal groups as the following:• control: used as (-ve ) control (normal diet) . Sp I : (+ve) control feed on Sp I % in diet for 3 weeksSp I + Sp2: (+ve) control feed on Sp 1 % in diet for 3 weeks and continued after EAC inoculation for 7 daysMMC : intra peritoneal injection ofMMC lmg/kg b.wt for 7 days