Biochemical and clinical study on carnitine shuttle in relation to some antibiotics in Rats

Carnitine is a hydrophilic natural substance acquired mostly through dietary meats and dairy products and is used by cells to transport hydrophobic fatty acids.The carnitine shuttle is responsible for transferring long-chain fatty acid across the barrier Mitochondrial dysfunction is increasingly implicated in the etiology of drug-induced toxicities. Mitochondria can be damaged both directly and indirectly by medications. Some antibiotics inhibit mitochondrial beta-oxidation enzymes. The aim of this study to evaluate the possible effects of some antibioticson carnitine shuttle. For this purpose three groups of rats (thirty rats for each) were used and assembled as follow: Group I ( control group ): 30 rats of this group were injected with normal saline subcutaneously (S.C) once daily (10 rats for 2 days, 10