The Effect of aged garlic extract (AGE) on dna damage induced by cadmium chloride toxicity in albino rats

Cd is toxic to a number of tissues including testis, prostate gland,liver, kidneys, and lung. It is classified by IARC as category Icarcinogen. Testis is the major target for acute Cd toxicity inexperimental animals. The major mechanisms involved in Cdcarcinogenesis are aberrant gene expression, inhibition of DNAdamage repair, inhibition of apoptosis and the induction of oxidative stress.AGE is an alternate source of fresh garlic which is odorless andricher in antioxidants that was found to be safe and effective inproviding health benefits. It has been found to protect DNA from damage.The present study was conducted to investigate the effect of AGEas an antidote against the toxicimmunity, genotoxicity, maleexamination of different organs.In the present study, one hundred male albino rats were randomlydistributed into four groups each of 25. The first group was used asnegative control group which was administered saline orally. Thesecond group was the positive control that orally administrated 2 gm/kg b.wt. of AGE daily for 15 days. The third group was orallyadministered 1/10 LDso of CdCl2 (7.5 mg/kg b.wt. daily for 15 days).The fourth group was orally administrated 1/10 LDso of CdCh followedby 2 gm/kg b.wt. of AGE daily for 15 days. Five animals weresacrificed from each group at 24h, 3, 5, 7, and 15 days postadministration. Blood samples were collected from control and treatedrats in tubes with and without anticoagulant EDT A after scarification