Inhibition of the Prohormone Convertase
Subtilisin-Kexin Isoenzyme-1 Induces Apoptosis
in Human Melanoma Cells

Faculty	Science	Year:	2014
Type of Publication:	ZU Hosted	Pages:
Authors:	Marwa Ahmed Tharwat Abdul Aziz Staff Zu Site Abstract In Staff Site
Journal:	Journal of Investigative Dermatology Journal of Investigative Dermatology	Volume:

Keywords :	Inhibition , , Prohormone Convertase Subtilisin-Kexin Isoenzyme-1 Induces Apoptosis in
Abstract:	Prohormone convertases (PCs) are endoproteases that process many substrates in addition to hormone precursors. Although overexpression of PCs is linked to carcinogenesis in some solid tumors, the role of subtilisin-kexin isoenzyme-1 (SKI-