Ciprofloxacin is one of 2nd generation flouroquinolonesextensively used as antimicrobial agent of many veterinarydiseases caused by gram + ive and gram -ive microorganisms aswell as mycoplasma. Whereas, doxorubicin is largely used asantineoplastic agent in treatment of various tumors .After one hour of incubation l-arginine (5; 10; 20 m mol) produced a significant increase in the percentage of acrosome reacted spermatozoa, while at high concentration (40; 50 m mol) it resulted in a significant reduction in the percentage of acrosome re