SYNTHESIS OF NEW PYRIMIDINE DERIVATIVES AND EVALUATION OF THEIR ANTICANCER AND ANTIMICROBIAL ACTIVITIES

Faculty Pharmacy Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Alaa Nabil Hassan Mustafa Ouf
Journal: Asian journal of pharmaceutical and clinical research Asian J Pharm Clin Res Volume:
Keywords : SYNTHESIS , , PYRIMIDINE DERIVATIVES , EVALUATION , THEIR ANTICANCER AND    
Abstract:
Objectives: The objective of this work is to synthesize new pyrimidine derivatives starting from ethyl 2,4-dioxo-4-(thiophen-2-yl)butanoate. Several oxadiazole, triazole, and thiadiazole moieties were incorporated into the pyrimidine backb
    
     
 
       

Author Related Publications

  • Alaa Nabil Hassan Mustafa Ouf, "A vitamin D C/D ring-derived compound with cytotoxicity", web of science, scoupus , pubmed, 2022 More
  • Alaa Nabil Hassan Mustafa Ouf, "Discovery of cytotoxic truncated vitamin D derivatives against both bortezomib‐sensitive and bortezomib‐resistant multiple myeloma phenotypes", web of science, scoupus , pubmed, 2024 More
  • Alaa Nabil Hassan Mustafa Ouf, "Novel Benzyloxyphenyl Pyrimidine-5-Carbonitrile Derivatives as Potential Apoptotic Antiproliferative Agents", web of science, 2022 More

Department Related Publications

  • Amany Mohamed Mohamed Elmahmoudy Sanger, "Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors", mdpi, 2022 More
  • Tarek Mohamed Salah Rashad, "Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors", mdpi, 2022 More
  • Amany Mohamed Mohamed Elmahmoudy Sanger, "Synthesis, Antibacterial Evaluation, and Computational Studies of a Diverse Set of Linezolid Conjugates", mdpi, 2022 More
  • Tarek Mohamed Salah Rashad, "New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors", mdpi, 2021 More
  • Tarek Mohamed Salah Rashad, "Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction", Taylor & Francis Group, 2021 More
Tweet