Summary: - The present study actually was carried out to spot light on the endoparasites among equine in the studied locality. During the period extending from October 2008 to October 2009, a total of 293 equine were investigated representing 106 horses, Epidemiological investigation of endoparasites revealed that the total infection rate of internal parasites was 56.7% and for horses, donkeys and mules were 43.4%, 62.2% and 63.6% respectively.The obtained results revealed that donkeys had higher percentages of helminths infestation than horses and mules.The percentages of infection of Strongyles, P.equorum, D. arnifieldi, O.equi, S.westeri, Anoplocephala Spp., Fasciola Spp. And Gastrodiscus aegyptiacus were 27.4% and 44.3%; 12.3% and 6.25 % ; 8.5% and 13.1%; 2.8% and 0%; 0% and 1.7%; 4.7% and 4%; 3.8% anThin blood film examination of 70 equine (45horses and 25 donkeys) revealed that the total infection rate of B.equi was 12.9%, infection rate was 13.33% and 12% in horses and donkeys respectively.The seasonal dynamics of internal parasites in horses revealed that Strongyles Spp., P.equorum, D. arnifieldi and Anoplocephala Spp. were found in all seasons of the year, O.equi and Fasciola Spp. were detected in autumn and summer only. While G. aegytpiaThe seasonal prevalence of B. equi, in horses was abundant during spring and summer 25% and18.18 % while in donkeys it was detected in autumn and summer seasons in 20% and 25% respectively.In respects to relationship between ages of examined equine and helminths infection, the obtained data revealed that adult horses are more susceptible to infection than other ages with Strongyles, D.arnifieldi , O.equi, Anoplocephala Spp. , Fasciola spp. B.equi was abundant in horses and donkeys in adult ages (2 ≤ 10 years) 83.3 % and 66.7% in horses and donkeys, respectively. In old horses and donkeys it was16.7 %and 33.3% respectively, while in young one it was 0% in both animals.In respect to the relation between sexes of examined equines and helminths infection , it was found that both male and female horses were infected by Strongyles, P. equorum, D.arnifieldi. while O.equi, Anoplocephala Spp. and Fasciola spp. in male only . GB.equi infection was abundant in male horses and donkeys (83.3% and 66.7% respectively) while in female it was 16.7% and 33.3% in horses and donkeys respectively.The most prominent clinical symptoms for helminths that recorded in this study were diarrhea, emaciation, colic, cough, fever, nasal discharge, lameness, oedema, pale mucous membrane and also there are apparently healthy animals.The clinical picture of piroplasmosis varied from acute to latent form. The most prominent clinical symptoms that recorded in this study were high fever, icteric mucous membrane, peticheal hemorrhage on conjunctiva, oedema in head, Cough, colic, sever aneIn the haematological investigation it was found that endoparasites infected group (G1) caused a marked decrease in red blood cell counts, hemoglobin content and Packed cell volume , whereas a highly significant increase in white blood cell counts . In adIn serum parameters, it was found that endoparasites infected group caused a highly significant decrease in albumin while a high significant increase in globulin and slightly (significant) decrease in total protein, and high significant increase in A/G raThe molecular method for diagnosis of equine piroplasmosis revealed that PCR technique was more sensitive than microscopic examination that identified 8 infected blood samples out of 20 examined blood samples representing 40%, B.equi identified in 7 infecThe efficacy of pyrantel tartarate 12.5% (Banminth) on Strongyle infested equine. The results revealed 100% reduction in egg count completely negative at 30 days post treatment.The efficacy of ivermectin 1% oral paste on Parascaris equorum infested horses. The results revealed 40% reduction in egg count after 30 days. While efficacy of ivermectin 1% oral paste on mixed infection of Strongyles and D.arnfieldi , the results revealThe blood picture of Strongyle infected equine after treatment with pyrantel tartarate 12.5%, revealed that increase in RBCs count, Haemoglobin content, and PCV%. While highly significant decrease in white blood cell counts at 30 days post treatment. DiffThe serum parameters of Strongyle infected equine, after treatment with pyrantel tartarate 12.5%, 1gm/10kg BW orally, revealed that a highly significant increase in albumin, while highly significant decrease in globulin, and non significant change in tota