| Abstract: |
In this investigation, the experimental induction of Listeriosis in rabbitswas carried out to study clinical, postmortem findings and histopathologicallesions of experimentally infected rabbits. Trials of rei solation and identification of reisolated isolates were carried out. In addition, antibiogram and trials oftreatment of experimentally infected rabbits with highly effective antibiotics were performed.The experimentally infected rabbits with Listeria monocytogenes VIaintraperitoneal, intranasal and oral routes showed clinical signs in the form of poor appetite; depression; ruffling fur; diarrhea soiled hindquarters, respiratorymanifestations, eye affection followed by emaciation then deaths. In addition,abortion and bloody stained vaginal discharges soiled hindquarters andposterior, delayed parturation and lor delivery of weak foeti that died within 24hrs postpartum. Postmortem examination of freshly dead rabbits revealed grosslesions in the form of sever congestion of liver, spleen, lung, kidneys, uterusbrain, and engorgement of both mesentery and sic bl.vs with blood. Sometimes,retention of urine and petechial and I or ecchymotic subcapsular hemorrhages in kidneys and abscesses formation in the skin. Also, some infected rabbitsshowed conjunctivitis followed by casiation of both eyes and end with completedestruction of eyes leads to blindness. In addition, presence of unclotted darkblood in the thoracic cavity with pneumonia and finally straw colored fluid inthe abdominal cavity and heamorrhage at the base of brain were recorded.Average body weights of experimentally infected rabbits with Listeriamonocytogenes were lower than non infected rabbits. Listeria monocytogenes isolates were reisolated with high percentage from lung of experimentallyinoculated rabbits via intranasal route; liver and spleen experimentallyinoculated rabbits via intraperitoneal route. Meanwhile, reisolated only fromliver of experimentally inoculated rabbits via oral route.
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