Some pharmacological studies on cefepime and ceftiofur sodium

Escherichia coli (E.coli) affect poultry industry causing major economic losses achieved by high morbidity and mortality, loss of body weight, and low egg production. Control of this microbe is an important for poultry industry which depend primarily on tCeftiofur sodium is β-lactamase resistant broad-spectrum cephalosporin antibiotic which has bactericidal activity against Gram-negative and Gram-positive bacteria.Cefepime hydrochloride is a parentral fourth generation cephalosporin antibiotic with an extended spectrum of antimicrobial activity against many Gram-negative and Gram-positive bacteria.The present work was carried out to evaluate in vitro antibacterial activity of ceftiofur sodium or cefepime HCl on E.coli strain and the effects of therapeutic dose of ceftiofur sodium (1mg/ kg b.wt. once daily) or cefepime hydrochloride(90mg/kg b.wt. twI-Antibacterial activity in vitro:The present study showed that MIC of ceftiofur sodium was 1.0 ug/ml against E.coli and MIC of cefepime HCl was 0.12 ug/ml against E.coli.The sensitivity E.coli to commercial discs of antibiotics namely ceftiofur, cefepime, ciprofloxacin, gentamicin, doxycycline, ampicillin, sulbactam and cefotaxime was determined. The order of antibacterial potency was as follows: cefepime > ceftiofur > geII-Effect on male fertility:Sixty male albino rats were divided into 3 equal groups each of 20 rats.- Group I, control group receive no medication.- Group II, treated with ceftiofur sodium (1mg/ kg b.wt. once daily) I/M for 5 successive days.- Group III, treated with cefepime HCl (90mg/kg b.wt. twice daily) I/M for 5 successive days.Five rats from each group were sacrificed after 1,2,4 and 8 weeks from drug administration to cover all spermatogenic cycle.The comparison between groups depends on:1) Weight of sexual organs.2) Epididymal spermatozoal examination.3) Histopathological studies.1) Weight of sexual organs.Intramuscular injection of ceftiofur sodium or cefepime hydrochloride in mature male rats :