Immune Response for Experimental Infection By Trichophyton Mentagrophytes in Guinea Pigs

The main objective of the current research was study the immuneresponse of Trichophyton mentegropbytes infection in experimentalanimals.This study was carried out on T. mentagrophytes var. tnentegrophytesin which were subjected for phenotypic identification and experimentalinfection in experimental animals.Phenotypic identification by macro and micromorphology werecarried by using S DA media. A Iso phenotypic idcnti fication by di ffcrentialmedia specially BCP and DTM.Primary and secondary experimental dermatophytoses were inducedIn thirty guinea pigs by spore suspension of T. mentagrophytes var.mentagrophytes to plucked and shaved areas of skin.The progress of lesions was monitored visually and their infectivitydetermined using microscopic examination for fungal elements in which skin scraping were collected at 3 days intervals.Lesions of primary cutaneous infections were described as redinflamed areas, forming a single large erythematous area, scaling wereexpanded over the entire infected area and progressive development of athick crust which on desquamation left smooth alopecic area. Completelesions healing and positive hair growth of all infected animals at day 30On reinfection, only slight inflammation was leaved followed byabsence of scales and regrowth of hair.