| Abstract: |
The third generation of cephalosporins retains safety of thefirst and second generation products but having longer half lives,lower MIC and wide spectrum of antimicrobial activity. Theresistance to beta- lactam antibiotics in both Gram - positive andGram - negative bacteria is mainly due to bacterial production ofbeta- lactamases which degrade beta- lactam antibiotics and thusmarkedly reduce their activity.A solution to this problem is the combination of a broadspectrum beta-Iactam antibiotic with a beta- lactamase inhibitor.Sulperazon (Sulbactam/ cefoperazone) represents a rational newsolution to the problem of resistant bacteria. Sulperazon not onlydelivers the broad spectrum effectiveness of advancedcephalosporine theory, but also deepens the antimicrobial spectrumof cefoperazone to include ~-lactamase producing pathogens thatotherwise resistant to ~ -lactam treatment. Sulperazon is indicatedfor the treatment of moderate to severe acute and chronic hospital -treated infections of the upper and lower respiratory tract, urinarytract, liver and biliary tract, skin and skin structures, as well assepticaemia, intra- abdominal infections, and joint infection.The present study aims to spot the light on the effect of thetherapeutic efficiency of the concurrent administration ofcefoperazone and sulbactam for treating E. coli infection 111chickens with regard to its effect on clinical signs, mortality rate,body weight gain, feed consumption and conversion, some liver andkidney functions, blood picture as well as histopathological study.The third generation of cephalosporins retains safety of thefirst and second generation products but having longer half lives,lower MIC and wide spectrum of antimicrobial activity. Theresistance to beta- lactam antibiotics in both Gram - positive andGram - negative bacteria is mainly due to bacterial production ofbeta- lactamases which degrade beta- lactam antibiotics and thusmarkedly reduce their activity.A solution to this problem is the combination of a broadspectrum beta-Iactam antibiotic with a beta- lactamase inhibitor.Sulperazon (Sulbactam/ cefoperazone) represents a rational newsolution to the problem of resistant bacteria. Sulperazon not onlydelivers the broad spectrum effectiveness of advancedcephalosporine theory, but also deepens the antimicrobial spectrumof cefoperazone to include ~-lactamase producing pathogens thatotherwise resistant to ~ -lactam treatment. Sulperazon is indicatedfor the treatment of moderate to severe acute and chronic hospital -treated infections of the upper and lower respiratory tract, urinarytract, liver and biliary tract, skin and skin structures, as well assepticaemia, intra- abdominal infections, and joint infection.The present study aims to spot the light on the effect of thetherapeutic efficiency of the concurrent administration ofcefoperazone and sulbactam for treating E. coli infection 111chickens with regard to its effect on clinical signs, mortality rate,body weight gain, feed consumption and conversion, some liver andkidney functions, blood picture as well as histopathological study.
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