Clinicopathological studies on the effect of vanadium pentoxide as anticarcinogenic

Vanadium is a heavy metal and trace element may be believedas a novel anticarcinogenic agent, helping in protection againstchemical cancer induction by DMBA which cause adenocarcinomain female-albino rats.One hundred and five female rats were divided into four gps.Gp.(1) of IS rats was the negative control, gp.(2) of 30 rats wasorally intubated by vanadium pentoxide (O.OSmg/kg B.WtI1S0 daysorally), gp.(3) of 30 rats was orally given DMBA(100mg/kg B.Wt,the dose divided into 4 weekly applications orally, dissolved in cornoil) after one month from the beginning of the experiment andgp.( 4) of 30 rats was cotreated with vanadium (O.OSmg/kgB.WtI1S0 days orally), then after one month DMBA was given as 4weekly applications orally, dissolved in corn oil with continuousadministration of V.Blood samples were collected from the retro orbital venousplexus for hematological and biochemical studies at 90, 120 andISO days from the beginning of the experiment. Tissue specimenswere taken at the same time from the liver, kidneys, lungs, spleen,mammary gland, oviduct and ovaries for histopathologicalexamination after sacrifaction of the rats.The rats appeared healthy in all groups but after the onset oforal intubation of DMBA, rats became dull, emaciated and easilydetached hair especially in the last four weeks of the study in gp.(3).In Group (4) received concomitant doses of vanadium and DMBAshowed mild signs of illness in the last 30 days of the experiment