Efficacy Of Ofloxacin And Ceftiofur Sodium In Chickens

The aim of this study is to evaluate the in vitro and in vivoantibacterial efficacy of ofloxacin, given orally at a therapeuticregimen (lOmg/kg B.WL); ceftiofur given intramuscularly attherapeutic regimen (0.2mg/kg B.Wt.) and their combination(ofloxacin 5mg/kg B. Wt. and ceftiofur 00.1 mg/kg B. Wt.) for 5successive days against experimentally E. coli infected chicks. Determining of minimum inhibitory concentration (MIC)and sensitivity test was done in vitro.In vivo, studying the side effects that could be reflected onliver and kidney functions and histopathological changesinvolving these vital organs. (1) Antibacterial activity in vitro:(A) The present study tested (MICs) of ofloxacin andceftiofur against E. coli of avian origin. E. coli washighly susceptible to ceftiofur more than ofloxacin. TheMIC value for ceftiofur was 0.05 ug/rnl which is lowerthan of ofloxacin 0.1 ug/ml,(B) Sensitivity of E. coli of avian origin to ceftiofur andofloxacin compared with other antimicrobial agents. Ceftiofur has been found to posses a more potent inhibitoryeffect on E. coli compared with ofloxacin, enrotloxacin,ciprofloxacin and flumequine.