Interaction Between Danofloxacin And Isoflupredone Acetate In Chickens

Danofloxacin is a new fluoroquinolone antimicrobial agent used in the veterinary field for prevention and treatment of respiratory diseases ofherbivores, swine and poultry. In poultry, danofloxacin is used for thecontrol of colibacillosis affecting poultry industry that causes majoreconomic losses. Isoflupredone acetate is a potent corticosteroid has greaterglucocorticoid activity than an equal quantity prednisolone. It also haspotent anti-inflammatory activity. It has been used in number of specificclinical conditions, including shock, CNS edema and ketosis but if sepsisis suspected, bactericidal antimicrobials are preferred as phagocytic activity is inhibited by glucocorticoids. The efficacy of therapeutic doses of danofloxacin, isoflupredone acetate and combination of the two drugs was investigated.In-vitro antibacterial activity of danofloxacin: The present study demonstrated that MIC of fluoroquinolone danofloxacin was much lower than that of older quinolone nalidixic acid against tested avian pathogen Escherichia coli 078.The sensitivity test is of a great value in recommendation of theeffective antibacterial agents. Our result revealed that the tested isolatewas most sensitive to danofloxacin than other tested quinolones(enrofloxacin, pefloxacin and nalidixic acid). The in-vivo efficacy of danofloxacin and isoflupredone acetatewas determined by carrying out an experiment against E-coli 078 byusing 200 Hubbard broiler chicks as follows: