effect of atenolol and propranolol on some biochemical and hormonal profils in experimentally induced diabetic rats

Diabetes mellitus and hypertension are both common disorders andit could be anticipated that they coexist in many patients.The clinical importance of selection of different antihypertensivedrugs for the diabetic patient is still under consideration the use of betablockers in diabetes mellitus has largely been restricted because ofadverse effects.In this study we try to study the effect of the non-selective B-blocker propranolol and cardioselective drug atenelol alone or withconcurrent treatment with oral hypoglycaemic drug (Glibenclamide onsome biochemical parameters as glucose, lactate, insulin, glucagon, freefatty acid, high denesitylipoprotein, low density lipoprotein, cholesterols,and triacyleglycerol at streptozotocin diabetic rat.A total of 80 adult male albino white rats are used in this studies.This rats are divided into 8 groups (each- of 10 rats).1- First group:Control group without treatment.11- Second group:Rats of this group are treated with propranolol (Inderal) at dose 5mg/kg B.V. orally/daily.