A total of 56 E.coli isolates and 8 salmonella isolates were identified biochemically by lactose fermentation , indole, citrate methyl red ,V P,TSI and sugar fermentation tests these isolateswere studied for antimicrobial susceptibility patterns by diskdiffusion method and micro dillution method. Chromosomal DNA and plasmide of 8 E.coli isolates included in this study were subject to PCR with primers specific to blaTEM, bla SHY ,blaOXAgenes.Antimicrobial susceptibility patterns Of 56 E.coli isolatesexamined by disk diffusion test out of 56 E.coli isolates 12isolates were resistant to cefotaxime (21.4%), 55 isolates were resistant to oxacillin (98.2%) withAbsence of complete susceptibility to oxacillin, 20 isolates were resistant to Gentamicin (35.7%) ,19 isolates were resistant to enrofloxacin (33.9%), 54isolates were resistant to doxycyclin (96.4%) with absence ofcomplete susceptibility to doxycyclin 9 isolates were resistant toLincospectin (16%) ,54 isolates were resistant to Amoxicillin (96.4%) with absence of complete susceptibility to Amoxicillin ,50isolates were resistant to amoxicillin- clavulanic acid (89.3%)and47 isolates were resistant to ampicillin - sulbacatam(83.9%).Antimicrobial susceptibility patterns of 8