| Abstract: |
One hundred and eighty male albino rats were divided into 3 main groups, each divided into 4 subgroups, to study the toxic and pathologicallesions of butylated hydroxyanisole, ethoxyquin and sodium metabisulfite.Rats of group 1 were divided into 4 subgroups. They received 0.5, 1, 2%BHA, respectively in the diet. The subgroup 4 was kept as control. Rats ofgroup 2 were divided also into 4subgroups and received 40, 200, 400mg/kg B~ ethoxyquin, respectively by gavage in corn oil and subgroup 4was kept as control. Rats of group 3 were divided into 4 subgroups andreceived 4, 6, 8 % sodium metabisulfite, respectively in the diet with addition of 50mg/kg thiamine to prevent thiamine deficiency due todestruction of this vitamin by sulfite, and subgroup 4 was kept as control.Five rats from each subgroup were sacrificed 1, 3 and 6 months in case ofgroup 1 while sacrificed 1, 2 and 3 months incase of group 2 and group 3 .The liver of rats received butylated hydroxyanisole (group 1),revealed variable lesions which differ according to the duration and doses.The lesions varied from congestion, lymphocytic infiltrations in the portalareas, hyperplasia of the bile ducts, cloudy swelling, vacuolar and hyDROPicdegeneration of hepatocytes and progressed to multiple areas ofcoagulative necrosis at 6months in subgroup 3. The most striking lesionswere detected in the stomach. They include congestion and round cellinfiltration, mild hyperplasia of the . squamous cells of the forestomachwhich proceeded to marked papilloma especially at the area of the limitingridge with severe acanthosis, hyperkeratosis and formation of papillary like projections in the submucosa. Hyperplastic effects were absent in the Iglandular stomach. The intestine showed focal desquamation, and round
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