A Biochemical Study On Glucose Metabolism After Partial Liver Resection

AIM OF THE WORKAs liver is considered to be the main regulator of body metabolic activities, specially that concerning with glucose, so the reduction of functioning liver mass may therefore suspected to cause alterations in the whole body glucose metabolism and homeostaThis work had been conducted to study the effect of acute experimental reduction of liver tissue mass (partial hepatectomy) on the whole body glucose homeostasis in rats. This can be carried out through studying the following items:1- Determination of serum level of glucose, insulin, triacylglycerol, and cholesterol.2- Studying the liver glycogen content.3- Assessment of serum levels of two enzymes involved in carbohydrate metabolism; glucose 6 phosphate dehydrogenase (G6PDH) and lactate dehydrogenase (LDH) that been considered as one of the liver function marker enzyme.The animals were then grouped according to the post operative feed period in time related manner. To eliminate the effect of anesthesia and surgery, laparotomy was performed on another group of animals that were classified afterwards in a similar manner l