| Abstract: |
Vitamin E is a fat soluble vitamin and it is an essential nutrient forthe growth and health of all species of animals. It has diverse roles due toits involvement in, for example, fetal death and re sorption, nutritionalmyopathy, retinal degeneration, erythrocyte hemolysis, prostaglandinbiosynthesis and T- and B-Iymphocyte responsiveness.Therefore, the present study was conducted to investigate thepathologic effect of hypervitaminosis E in different durations and doseson the different organs of female and male albino rats.In the present study, a total of 150 albino rats divided into fivegroups (each group contained 30 rats) were used. Rats of group (1) hadreceived 500 mg vitamin E / kg B.Wt daily, group (2) had received 1000mg / kg B.Wt daily, group (3) had received 2000 mg / kg B.Wt daily andgroup (4) had received corn oil only by a dose of 3 ml / kg B.Wt daily for6 months while group (5) was kept as a control. The drug was dissolvedin corn oil and was given by stomach tube. Ten rats from each group weresacrificed 2, 4 and 6, months post administration (PA).The liver of rats received vitamin E by a dose of 1000 mg / kgB.Wt and 2000 mg / kg B.Wt either for short or long period revealedlesions of variable degrees. The lesions were congestion of the bloodvessels, haemorrhages, leukocytic infiltrations, lymphocytic aggregationand fibrous tissue proliferations as well as evidence of vacuolar andhyDROPic degeneration were seen.The kidneys showed congestion of the blood vessels,haemorrhage, peritubular edema, renal casts, leukocytic infiltrations and fibrous tissue proliferations replaced the degenerated renal tubules.
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