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Glycation as an atherogenic modification of LDL
Faculty
Pharmacy
Year:
2008
Type of Publication:
Article
Pages:
378-384
Authors:
Soran, Handrean, Charlton-Menys, Valentine, Durrington, Paul N, Sharma, Reena, Younis, Nahla, Elseweidy, Mohamed
DOI:
10.1097/MOL.0b013e328306a057
Journal:
CURRENT OPINION IN LIPIDOLOGY LIPPINCOTT WILLIAMS \& WILKINS
Volume:
19
Research Area:
Biochemistry \& Molecular Biology; Endocrinology \& Metabolism; Cardiovascular System \& Cardiology
ISSN
ISI:000257779400008
Keywords :
cardiovascular disease, glycation of LDL, oxidation of LDL, small dense LDL
Abstract:
Purpose of review To highlight the potential importance of glycation as an atherogenic modification of LDL in people with diabetes and those without. Recent findings Small dense LDL which is known to be most closely associated with atherogenesis is more susceptible to glycation than more buoyant LDL. Glycation and oxidation of LDL appear to be intimately associated. Summary Glycation of LDL occurs chiefly due to the nonenzymatic reaction of glucose and its metabolites with the free amino groups of lysine in which LDL is rich. Higher concentrations of glycated LDL are present in individuals with diabetes than in those without, but, even in the latter, there is generally more circulating glycated LDL than oxidatively modified LDL. Probably, oxidation and glycation of LDL are at least partially interdependent, but both prevent LDL receptor-mediated uptake and promote macrophage scavenger receptor uptake. The recognition that LDL glycation is at least as important as oxidation in atherogenesis may lead to improvements in our understanding of its mechanism and how to prevent it.
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