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Extractive colorimetric method for the determination of dothiepin hydrochloride and risperidone in pure and in dosage forms
Faculty
Pharmacy
Year:
2008
Type of Publication:
Article
Pages:
1092-1096
Authors:
Hassan, Wafaa El-Sayed
DOI:
10.1248/cpb.56.1092
Journal:
CHEMICAL \& PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN
Volume:
56
Research Area:
Pharmacology \& Pharmacy; Chemistry
ISSN
ISI:000259166600005
Keywords :
colorimetry, ion pair, dothiepin hydrochloride, risperidone, pharmaceutical analysis
Abstract:
Three rapid, simple, reproducible and sensitive extractive colorimetric methods (A-C) for assaying dothiepin hydrochloride (I) and risperidone (II) in bulk sample and in dosage forms were investigated. Methods A and B are based on the formation of an ion pair complexes with methyl orange (A) and orange G (B), whereas method C depends on ternary complex formation between cobalt thiocyanate and the studied drug I or II. The optimum reaction conditions were investigated and it was observed the calibration curves resulting from the measurements of absorbance concentration relations of the extracted complexes were linear over the concentration range 0.1-12 mu g ml(-1) for method A, 0.5-11 mu g ml(-1) for method B, and 3.2-80 mu g ml(-1) for method C with a relative standard deviation (RSD) of 1.17 and 1.28 for drug I and II, respectively. The molar absorptivity, Sandell sensitivity, Ringbom optimum concentration ranges, and detection and quantification limits for all complexes were calculated and evaluated at maximum wavelengths of 423, 498, and 625 nm, using methods A, B, and C, respectively. The interference from excipients commonly present in dosage forms and common degradation products was studied. The proposed methods are highly specific for the determination of drugs I and II, in their dosage forms applying the standard additions technique without any interference from common excipients. The proposed methods have been compared statistically to the reference methods and found to be simple, accurate (t-test) and reproducible (F-value).
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