This work aimed to study the metabolic changes after augmentation enterocystoplasty at different lengths of ileum as a tool for treatment ofbladder cancer. A total of twenty clinically healthy adult males and females mongrel dogs were used as an experimental animal model. These dogs were divided into four main groups. The first group of five dogs served as control and the last three groups ac1- Biochemical study. Different biochemical parameters weremeasured in sera and urine for control and operated groups, such ascreatinine (mg/dl), sodium (m mol/dl), potassium (m mol/dl), and totalprotein (mg/dl) 2-Urine culture and analysis study. Urine culture was done, and different parameters were analysed in urine samples. These were specificgravity, pH (unit), blood (ug/L) and leukocyte (cells/ul). 3- Blood gases study. Different parameters were measured in blood to monitor the blood gases changes. These were, pH (unit), PC02 (mmHg), P02 (mm Hg), and HC03 (m mol/I). The operation was done bycontinuity of the intestinal tract was re-established by a one layerextramucosal end-to- end anastomosis. The isolated segment was folded ina cup patch by U-form technique. Subtotal cystectomy just above the