Immunosuppressive Effect Of Florfenicol, A Comparative Study

Florfenicol is a novel broad-spectrum antibiotic for the treatment ofbovine respiratory disease (BRD) caused by multiple bacteria andMycoplasma, bacterial meningitis and enteritis of calves. Florfenicol isbelonging to the family that including thiamphenicol and chloramphenicol.These drugs are similar in structure with substitution of fluorine atom in thesite of hydroxyl group of chloramphenicol in case of florfenicol, they actby _ inhibition of bacterial protein synthesis at the ribosome. Bacterial, .resistance to both chloramphenicol and thiamphenicol is due to thepresence of chloramphenicol acetyl transferase (CAT) in these bacteria ..Several bacterial strains that are highly resistant to both chloramphenicoland t~iamphenicol due. to CAT prr~cti ~n are hi ghl y sensitiv.e. toflorfenicol, Also florfenicol has a superior m vitro antibacterial activitycompared with chloramphenicol and thiamphenicol.The present study was conducted to throw the light on theimmunomodulating effects of this chloramphenicol analogues, florfenicolon fish, chickens and buffalo-calves in1mune system, and to the extent thatthe immunol~gical similarities between~he different species.In this investigation, one hundred and sixty, Nile catfish were used.They were divided into four equal group. The first group left as a control in,the three species. The 2nd and the ~th group administered therapeuticregimen of florfenicol 10 mg/kg b.wt for 10 consecutive days mixed with. ’the finished _ feed. The 4th group intraperitoneaIIy administered Aeromonas