Certain Metabolic Studies on the Effects of Insecticides

Insecticides either organophosphates or pyrethroids are used in large scale especially in agriculture around the world. Toxic exposure to thesetoxic chemicals is a serious global public health problem. This work has been designed to explore some biochemical suspected deleterious effect of two important insecticides, karate (pyrethroids) and Drusban (organophosphorus) in guinea pig.Thus we have choiced two doses, 1110 LD50 and 11100 LD50 and thenumber of animals (male) totally were 152 animals grouped as follows:- Growing (7 6 male) guinea pig 17 5± 15 gm. - Mature 76 male guinea pig 400±20 gm. - Each main group subdivided into 4 groups (each of 16 animals), two of them administered the karate and the other two administered theDrusban.- The control group was 12 animals and administered water (0.1 mlinstead the insecticide).- The time of administration was 7 successive daily applications and 14 applications and sampling followed 24 hrs after the last application. The obtained results related: Cholinesterase activity in serum showed significance DROPpfollowing different doses of both tested insecticides (Karate &Drusban). There was a clear positive correlation between the DROPpingof AChE: serum and both the dose of insecticide as well as the times ofadministration.