Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Spectrophotometric determination of hyoscine butylbromide and famciclovir in pure form and in pharmaceutical formulations
Faculty
Science
Year:
2008
Type of Publication:
Article
Pages:
785-792
Authors:
Gouda, Ayman A, El Shafey, Zeineb, Hossny, Nagda, Ei-Azzazy, Rham
DOI:
10.1016/j.saa.2007.09.010
Journal:
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY PERGAMON-ELSEVIER SCIENCE LTD
Volume:
70
Research Area:
Spectroscopy
ISSN
ISI:000258363300012
Keywords :
hyoscine butylbromide, famciclovir, spectrophotometry, ion-pair complex, acid dyes
Abstract:
A simple, rapid, and extractive spectrophotometric method was developed for the determination of hyoscine butylbromide (HBB) and famciclovir (FCV) in pure and pharmaceutical formulations. These methods are based on the formation of yellow ion-pair complexes between the basic nitrogen of the drug and four sulphonphthalein acid dyes, namely; bromocresol green (BCG), bromothymol blue (BTB), bromocresol purple (BCP) and bromophenol blue (BPB) in phthalate buffer of pH range (3.0-3.5). The formed complexes were extracted with chloroform and measured at 420, 412, 409 and 415 run for HBB and at 418, 412, 407 and 414 nm for FCV using BCG, BTB, BCP and BPB, respectively. The analytical parameters and their effects on the reported systems are investigated. Beer's law was obeyed in the range 1.0-20 mu g mL(-1) with correlation coefficient (n = 6) > 0.9997. The molar absorptivity, Sandell sensitivity, detection and quantification limits were also calculated. The composition of the ion pairs was found]:I by Job's method in all cases and the conditional stability constant (K-f) of the complexes have been calculated. The free energy changes (Delta G) were determined for all complexes formed. The proposed methods have been applied successfully for the analysis of the studied drugs in pure and pharmaceutical formulations with percentage recoveries ranges from 99.84 to 100.26. The results were in good agreement with those obtained by the official methods. (C) 2007 Elsevier B.V. All rights reserved.
Online
PDF
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف