Some Biochemical Studies On Some Antioxidants In Blood Of Diabeticrats

Many studies have suggested that, an imbalance in the antioxidantprotective mechanism leading to oxygen stress in the cells is identified as acommon factor in many disorders including diabetes mellitus. In diabetes mellitus reactive oxygen species are increasingly formed by the auto- oxidation of glucose and glycosylated proteins. Oxygen-derived radicals and reactive oxygen species are known toIncreased oxidative stress associated with diabetes occur as a result ofincreased free radicals generation, decreased levels of antioxidants and/orimpaired regeneration of reduced forms of the antioxidants. Recently, it has been suggested that vitamin A, E, C, carotene and glutathione (GSH) provide antioxidant defences by their ability to exist in reversible oxidized and reduced forms. The enzymes sdietary supplementation the experimental rats with some important nutrient antioxidants, vitamin E, vitamin C and selenium for a period of 28 days before rendered diabetics by streptozotocin injection.