Anti-Hepatotoxic Effect of Some Medicinal Plants

Summary:- The present study aimed at screening the efficacy of Apiumgraveolens (A.graveolens), Cynara scolymus (C.scolymus),Glycyrrhiza glabra (G.glabra) and Salvia officinalis (S.officinalis),on liver dysfunction induced by carbon tetrachloride (CC14),compared to a standard silymarin as a settled anti-hepatotoxic agent.In addition to focus a spotlight on the prophylactic and therapeutictreatment efficacy of Siofficinalis and C.scolymus.This study was performed on 29 groups of albino rats (each of5 rats), in which, three experiments: pilot (7 groups), pretreatmentCC14 (11 groups) and post treatment CC14 (11 groups) were done.The obtained results were summarized into the following:1- Pilot experiment: -Showed that A.graveolens, C.scolymus, G.glabra andS. officinalis exerted a significant decrease of the elevated serumenzymes level (ALT and AST) caused by LP. injection ofCC14.On comparison to the relative doses of the standard silymarin, therewere no significant increases in the tested enzymes except for theG.glabra treated rats.11 - Pretreatment CCI4 experiment:A - Biochemical findings: -On comp-arison to the control group, a significant decrease inserum ALT levels were detected among rats treated with S.officinalis(100 and 200mg / kg) and those treated with C.scolymus (50 mg / kg).