Pharmacological Effects of Some Recent Antimicrobials on Catfish

The present work was conducted to evaluate the antibacterial effectof neomycin and gentamicin in catfish (Clarias lazera) were used toevaluate the efficacy of both drugs. The effects on blood picture, liver andkidney functions, and histopathological examination had been alsoinvolved. The obtained results are summarized as follow:1- Efficacy of gentamicin and neomycin:The in vivo treatment measures were applied in catfishexperimentally infected with A. hyDROPhila. The results obtained provedthat gentamicin and neomycin were markedly effective in vivo against A. -hyDROPhila microorganisms.Treatment with therapeutic regimen of both neomycin and gentamicin, displayed complete recovery from the gross pathological lesion. 2- Effects of neomycin and gentamicin on blood constituents of catfish:Healthy fish treated with neomycin showed no changes in bloodconstituents meanwhile, the fish treated with gentamicin showed asignificant decrease ofRBCs count, hemoglobin concentration and PCV%.Infected fish treated with neomycin and gentamicin showed a significant decrease of RBCs counts, Hb concentration and PCV%.