| Abstract: |
The present work is performed to study the pathological effects of mercuric chloride and lead acetate on the different body organs of albino rats.Seventy-five healthy mature rats of both sexes were used in this work. They were divided into five equal groups. The I SI and 2nd groups were given 1/10 and 1120 LDso mercuric chloride twice weekly for 1, 3 and 5 months. The 3rd and 41h groups were given The clinical signs observed on rats, which received mercunc chloride, were emaciation, ruffled hair coat, loss of appetite, dyspnea, muscleincoordination specially at 5 months P.A. The kidneys showed edema, hemorrhages, congestion, some degenerative changof some renal tubules, dilatation in glomerular space as well as chronicinterstitial nephritis. The liver revealed congestion, some degenerativechanges, proliferation in bile duct and Kupffer cells, necrosis, few lymphocytic and fibroblastic proliferation in portal areas andenlargement in the nuclei of some hepatic cells. The brain revealedcongestion, edema, hemorrhage, neuronal degeneration, neuronophagia,satellitosis and focal areas of encephalomalacia in addition
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