Clinicopathological changes in experimentally arteriosclerotic laboratory animals before and after treatment with some plant extracts

Hyperlipidaemia as the main cause of atherosclerosis which is one of the most serious factor, causingcardiovascular cF·; ’;Ises in man and animals is mainly associated with dietery fat intake and lipid metabolism. Treatment and prophylaxis with some plant(10) as control. Group A, divided into 2 main groups (I & II) where ratsfed chole-rerol (0.5 gm/kg b.wt.) for 12 weeks and injected or vitamin D2(7.5 mg kg b.wt.) for 10 days respectiv~ly Ior induction ofhypercholesterolemia and atherosclerosis. Each main group divided into subgroupcd (a), (b), (c) and (d), subgroup (a) was kept a<.; atherosclerotic control. Subgroups (b) ,(c) and (d) were treated orally for 12 weeks with garlic powder (50 mg/80 gm b.wt.)Nigella sativa oil and nicotinic acid respectively, each group wassubgroupcd to (a) , (b) (c), subgroups (b) and (c) were given cholesteroland vitamin D2 respectively for induction of atherosclerosis. Group C