Anti-Hepatotoxic Effect Of Apium Graveolens

The present study aimed at screening the efficacy of Apium graveolens (A. graveolens) methanolic seeds and aqueous leaves extracts on liver damage induced by carbon tetrachloride (CCL4), compared with a standard silymarin as a settled anti-hepatotoxic ageOur results were summarized into the following: Pilot experiment: -A ] CCl4 induced hepatotoxicity :Carbon tetrachloride (CC4) diluted in olive oil (1 : 1 V/V) wasinjected intraperitoneally (LP.) at a single dose of 1 ml/kg B.wt. to onegroup of albino rats and 2 ml/kg B.wt. to. another group. The levels ofserum AL T & AST were estimated in the two tested groups to reflect thedegree of liver intoxication induced by CC4 . It was found that 2 ml /kgB.wt. CC4 induced acute hepatitis than 1 ml/kg B.wt. CCk Bloodsamples were collected 48 hs. After CC4 intoxication. B ] Anti-hepatotoxic effect of Apium graveolens seeds extract: One group of albino rats was injected intraperitoneally with CC4(2 ml /kg B.wt. in olive oil) at the first day of the experiment followed