Experimental Pathological Studies On The Effect Of Some Newly Used Antibiotics An Albino Rats

Norfloxacin, cefoperazone and cefotaxime are newly used antibiotics for animal and human treatment. Norfloxacin is a synthetic antibacterial agent derived from nalidixic acid and is highly effectiveagainst Gram positive and Gram-negative pathogens. Cefoperazone and cefotaxime are members of the third generation cephalosporins produced by the mould Cephalosporium acremonium and they areeffective against Gram negative and some Gram-positive pathogens.Hundred and sixty albino rats were used to study the adverse effects of norfloxacin, cefoperazone . and cefotaxime. They were equally divided into 8 groups: I1G administered glacial acetic acid 1% (group 1), represented as a control group for groups 2 andadministration of 60 mg/kg. B.wt. of norfloxacin (group 3). I1Madministration of saline (group 4), represented as a control group forgroups 5,6,7 and 8. I1M administration of 18 mg/kg. B.wt. of cefoperazone (group 5), I1M administration of 324 mg/kg. B.wt. of cefoperazone (group 6), I1M administered 18 mg/kg. B.wt. ofcefotaxime (group 7) and I1M administration of 324 mg/kg. B.wt. ofcefotaxime (group 8). The liver (norfloxacin) was congested and enlarged .In late stage it became pale in color. The hepatocytes showed degenerative changes mainly hyDROPic and fatty change with both therapeutic and toxic doses. Coagulative necrosis appeahepatitis and hyperplasia of the bile duct epithelium appeared with