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Spectroscopic, Thermal and Biological Studies of the Coordination Compounds of Sulfasalazine Drug: Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) Transition Metal Complexes
Faculty
Science
Year:
2008
Type of Publication:
Article
Pages:
1585-1591
Authors:
El-Wahed, Mohamed Gamal Abd, Refat, Moamen Salah, El-Megharbel, Samy Mohamed
DOI:
10.1248/cpb.56.1585
Journal:
CHEMICAL \& PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN
Volume:
56
Research Area:
Pharmacology \& Pharmacy; Chemistry
ISSN
ISI:000260521600013
Keywords :
infrared spectrum, electronic spectrum, thermal analysis, sulfasalazine, antimicrobial activity
Abstract:
The complexations of sulfasalazine (H(3)Suz) with some of transition metals have been investigated. Three types of complexes, {[}Mn(HSuz)(-2)(H(2)O)(4)]-2H(2)O, {[}M(HSuz)(-2)(H(2)O)(2)]center dot xH(2)O (M=Hg(II), ZrO(II) and VO(II), x=4, 8 and 6, respectively) and {[}M(HSuz)(-2()Cl(H(2)O)(3)]center dot xH(2)O (M=Cr(III) and Y(III) , x=5 and 6, respectively) were obtained and characterized by physicochemical and spectroscopic methods. The IR spectra of the complexes suggest that the H(3)Suz behaves as a bidentate ligand. The thermal decomposition of the complexes as well as thermodynamic parameters (Delta E{*}, Delta H{*}, Delta S{*} and Delta G{*}) were estimated using Coats-Redfern and Horowitz-Metzger equations. In vitro antimicrobial activities of the H(3)Suz and the complexes were tested.
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