Effects of some antimicrobials on autonomic nervous transmission

The present study was conducted to investigate theeffect of antimicrobials : gentamicin, oxytetracycline,Furaltadone and sulphadimidine on the adrenergic trans- mission by using perivascular stimulated innervatedrabbit jujenum, transmurally stimulated rat vas deferens, and field stlmulated mouse vas deferens preparations.All tested drugs significantly (P<O. 01) blocked the twi tchh responses of the innervated rabbi t jujenum toperivascular stimulation. After 20 minutes, gentamicin (0.2 mg /rnl) elicited 48.80% + 2.50 whereas 0.4 mg mg/ml blocked 78.50X+ 2.88 of the jujenum response, oxytetracycline (0.4 mq Zrn L) blocked 49.50% +6.64, whereas 0.8 rng/rnl blocked 71.58%+ 3.36 of the jujenum response. Furaltadone (0.8 mq Zm L) induced 74.71% ± 6.82 blockage in the response. Sulphadimi- dine (1 mq z m L) elici ted 78.11% ± 5.28 blockage of therabbit jujenum responses.All tested drugs significantly (P<O.Ol) blocked the inhibitory responses of the rabbit jujenurn to exogenousadrenaline (0.4 ug/ml) except oxytetracycline. Gentamicin (0.4 mg /ml), fural tadone (0.8 mg /ml) and sulphadimidine(1 mg/ml) blocked 48.61% + 2.53, 65.19% + 3.80 and 30.23