| Abstract: |
OUl’ study pE!:cfo.crn0.H3 on oxperi.fl)(:~nta 1 an i.ma 1 s (Al b i.no rat) for s t.udyLno t.he prOCE,!S s of rnarnma ry ca 1’(::lnoge])e5 j, s .Virg,tn f erna Le rats 55 days olc1w~?:cE! adrnirttsten?d 7,.12dimethyl be n z (a)anUl.caco{w ”DJl-lBA” cclfcinogl’:m e l.ono .i nfirst group, d.1.rnothyl bE)))l. (a) antl) raCHfl.O and BCG E< SImn1unst3.rilulant c1llta.gonIz:i.ng imnll..lnosupp:ressive effect ofcarcinogHn in second one. Tho third group were aarnintstE!,cE’.d BCG eLorie cl:, irnrnuflst’:i,ml..llaflt and the fourth one as cor.t.r o I nogat,1.Vt’.! 9 roup . FIvE.; ani.ma I s from HdChgroup ;.vere sa(:r.}flc(~c1 monthly for fl v e rno nth s t.h e t.e rrn ofour t;xperlrnent_ The early stage of our experiment revealed thelmmuno:”;upp:cE.!S sivo (,;ffc’}ct of ca1’clnogon. ThE; inte,nnedlat(~stag,~ d(~notec1 VJ(~1.1 dOVE;;lopod lrniliullo ro::;:ponse in thoseanJ,nlal s gl v (::,;0 carclnogon ”DHBl,” alono 01’ wi.t.h BCG and aru.ma ls d o s ed BCG ’’:I1.one as :.i.lnrnl..i.o(! stiinul~jrlt.All cll ni,cal pa :cd.rnotE:; r s::,tudlE,d Inclucllng ,immu n () 1 00 ,1.Ci:t 1; ,1!d.(~ina tu 1 o!)j.ca 1 and bJ.uch Ufll:iC:d 1 Pf:! :ca motu r sw)r( Goor’l13.j·Jd i.ud togethu:r.’ .i.n ;::1 f)cJud actlvu’ stat.o . Addl.1\) tu thl”’selho il} ;: topathul ()]lcalrev E;!a 1 ecr Pd r’afll~:,)tE:! rshyper[J[oll.fE.;Iul.’.ed vI’u’..;th d8v~’~lop(~t] le; fll,icl’oscoptcadf!nO(!arc:i.1l0illd.toU::; gruwttl. In the lat(~:t· stagE’! ti’J(; antniclls showed in,”J(: :co::coplc ad()/lOCd ,cc:i.noffld.toU:”; rnarnmc’t I’y 9 r owt.h 1 n 6n1ma1::; groupsthose dOSE)(] Cd. rc;J.rJogOilalorw or incornb:i.natlonw i.t.h BCG lmiTlUflE, as s ti rnu 1. e r.t.Th:i s acornpainod wlth contin U,:Jtl011 of goo(3 physloloJlcal
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