Clinical neuromuscular paralysis and hypotension most frequently :cur when antibiotics are used in combination with neuromuscular pressants or antihypertensive drugs. By improving our understanding of mechanism by which each drug exerts its action, we wilThe present study, a brain-child of the previous ’concept, is designedfathom the possible effects of danofloxacin and spiramycin on theonomic neurotransmission .Adrenergic neurotransmission:-Isolated preparations:-Effect on the perivascular stimulated rabbit jujenum:- Both danofloxacin and spiramycin elicited a concentration-related depressant effect on the perivascular stimulated rabbitjujenum. Danofloxacin; 0.03,0.06 and 0.12 mg/ml elicited a 39.35% ±3.75,56.38% ±2.85 and 65.90% ± 1.70 blockage respectively of therabbit jujenum control responses after 30 minutes.Spiramycin; 0.25, 0.5 and 1.0 mg/ml blocked 46.90 ± 5.95,