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Antihepatotoxic Activity and Chemical Constituents of Buddleja asiatica Lour
Faculty
Pharmacy
Year:
2009
Type of Publication:
Article
Pages:
11-19
Authors:
Wink, Michael, El-Domiaty, Maher M, Aal, Mahmoud M. Abdel, Abou-Hashem, Maged M, Abd-Alla, Rehab H
Journal:
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES VERLAG Z NATURFORSCH
Volume:
64
Research Area:
Biochemistry \& Molecular Biology; Pharmacology \& Pharmacy
ISSN
ISI:000264436900003
Keywords :
Buddleja, Iridoid Glycosides, Antihepatotoxic Activity
Abstract:
A new natural compound, named 6-0-(3{''},4{''}-dimethoxycinnamoyl) catalpol, was isolated from the defatted alcoholic extract of the flowering parts of Buddleja asiatica Lour. (family Scrophulariaceae). Other separated known compounds included steroids (beta-sitosterol, stigmasterol, stigmasterol-O-glucoside, beta-sitosterol-O-glucoside), iridoid glucosides (methyl catalpol, catalpol, aucubin), phenylpropanoids (isoacteoside and acteoside), a triterpene saponin (mimengoside A), flavonoids (diosmin and linarin) in addition to the free sugars mannitol and sucrose. The structures of the isolated compounds were established by (1)H and (13)C NMR and mass spectrometry. Furthermore, the polar fraction of the flowering parts and the roots showed substantial antihepatotoxic activity comparable to that of the lignan silymarin.
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