Clinico Pathological Studies on Some Drug Interactions In Albino Rats

Antibiotics are widely used in veterinary practice. Among thesedeveloped antibiotics gentamicin which is a member of aminoglycosidesgroup and cephradine which belong to the first generation of cephalosporingroup. Recently many antibiotics losses its activity due to development ofresistance. So the uses of antibiotics combination indicated to overcome thebacterial resistance.Two hundred and twenty albino rats of about 200 gm average weightwere used in this work and divided into two main groups A and B. Group Awas of one hundred and ten rats divided into 6 subgroups. The 1st, 2nd, 3rd,4th and 5th subgroups, each of 20 rats, while the 6th subgroup consists of 10rats represent the normal control, the 1 st, and 2nd subgroups injected withlow and high therapeutic doses of gentamicin, while the 3rd and 4th onesinjected with low and high therapeutic doses of cephradine. The 5th oneinjected with low therapeutic doses of both gentamicin and cephradine.Group B was of one hundred and ten albino rats divided into 6subgroups. First the rats infected intraperitoneal with staphylococcus aureus, then the 1 st and 2nd subgroups were treated with low and high therapeutic doses of gentamicin. The 3rd and 4th subgroups were treated with low and high therapeutic doses of ceof 10 rats which was infected non treated and used as infected control grou.p