Pyridazine Derivatives and Related Compounds, Part 28. Pyridazinesulfonamides: Synthesis and Antimicrobial Activity

Faculty	Science	Year:	2009
Type of Publication:	Article	Pages:	92-102
Authors:	Deeb, Ali, El-Mariah, Fatma, Nassar, Ekhlass, Hosny, Mona	DOI:	10.1080/10426500802080246
Journal:	PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS TAYLOR \& FRANCIS LTD	Volume:	184
Research Area:	Chemistry	ISSN	ISI:000261874700009
Keywords :	3-Substituted aminopyridazines, N-substituted pyridazine-3-sulfonamides
Abstract:	The reaction of 3-chloropyridazine 1 with N -(un)Substituted 4-aminosulfonamides 3 gave the 3-substituted aminopyridazines 4. Also In addition, pyridazine-3-sulfonamides 7 were prepared from the reaction of pyridazine-3-sulfonylchloride 6 with different amines. All of these derivatives have been characterized by analytical and spectroscopic studies, and also were tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.
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