Comparative Studies on Attenuated And Inactivated Rift Valley Vaccines

R VF is an acute infectious viral disease affecting many species ofanimals and· man. Animal vaccination is the most important controlmeasurement’ in endemic areas. The inactivated and attenuated R VFvaccines were used. It is important to compare between both types. Firstlythe two vaccines were inoculated in two groups of sheep includingpregnant ewes. Neither thermal reaction nor abortion were recorded allover period of experiment, except that there was an elevation of bodytemperature for ’one day post vaccination with attenuated vaccine. T-cellresponse as cellular immune response of sheep vaccinated with liveattenuated vaccine was significantly high at 1-5 week post vaccination,and also that of sheep vaccinated with inactivated vaccine wassignificantly at 2-5 week post vaccination, with less value than in animalsvaccinated with attenuated vaccine. The leucocytic count of animalsvaccinated with live attenuated vaccine was-significantly increased at 1-5week post vaccination and it was significantly increased at 2-5 week foranimals vaccinated with inactivated vaccine. Differential leucocytic countpost vaccination revealed that lymphocytic count was significantlyincreased after vaccination with both type of vaccines, while neutrophilcount was significantly decreased after vaccination. Some kidney andliver function tests were showed non significant changes after vaccinationwith both type of vaccines. Total protein values had non significantchanges after vaccination with both vaccines, while albumin values wereshowed significant decreased at 2-6 weeks post vaccination with both