Clinico-Pathological Studies on Chicken Infected And Vaccinated With Newcastle Disease Virus

Newcastle disease is a highly contagious, septicaemic , fatald destructive disease which attacks chiefly chickens and turkeysd causes high economic losses.The present work was designed to study the clinicopathologicalhistopathological changes and to evaluate the differentrological techniques for detection of immune response in infectedd vaccinated chickens with Newcastle disease. The current work was conducted as follows: One hundred and fifty chicks, one day old, were divided intoThe first group (70 chicks) was vaccinated with La in drinking water , then challenged , after threevaccination wi th velogenic viscerotropic Newcastleisease virus, intramuscularly. The second group (40 chicks) wasxperimentally infected wi th velogenic viscerotropic Newcastle virus , intramuscularly. The third group (40 chicks) was as non treated control group_ Blood samples were collectedeach chick for determination of cellular immunity ( Total andserological ti terifferential Leucocytic Counts Haem -, .qglutination Inhibition Titer and Serum Neutralization Test Titer)d some biochemical parameters ( Serum Protein , Alanine Amino - unsferase {ALT} Aspartate Aminotransferase {AST} , Cholesterol